id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292519-dod8k0xa	Goldstein, Mark R	Does apolipoprotein E genotype predict COVID-19 severity?	2020-04-27		.txt	text/plain	696	36	46	A challenge facing the medical community caring for coronavirus disease 2019 (COVID-19) patients is predicting who will eventually progress to severe illness and even death, which is usually from acute respiratory distress syndrome (ARDS) [1] . We hypothesize that the apolipoprotein E4 (apoE4) genotype may predict the propensity to manifest rapid and severe illness with COVID-19. Of interest, apoE4 has also been associated with some of the comorbid risk factors associated with severe COVID-19, such as atherosclerosis and hypertension [4, 8] . Therefore, it is possible that having one or two copies of apoE4 predisposes one to be at high risk to progress to severe illness from SARS-CoV-2, by virtue of a sequence of robust innate immune response, followed by cytokine storm, and resulting ARDS. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE ε4/ε4 genotype accelerates HIV disease progression	./cache/cord-292519-dod8k0xa.txt	./txt/cord-292519-dod8k0xa.txt