id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293359-6iw7dnz6	Wang, Laureen Yi-Ting	COVID-19 treatment with lopinavir–ritonavir resulting in sick sinus syndrome: a case report	2020-06-30		.txt	text/plain	1871	141	49	Besides being at higher risk of complications of COVID-19 infection, patients with underlying cardiovascular disease are more likely to develop cardiac-related side effects of treatment. 1 Our patient, with COVID-19 pneumonia, was started on lopinavir-ritonavir and developed sinus arrest. We want to highlight the potentially fatal side effect of lopinavir-ritonavir-induced bradyarrhythmia with this case report. [4] [5] [6] In the recent randomized controlled study in Wuhan China, no benefit was found in time to clinical improvement with 14-day treatment of lopinavir-ritonavir compared with standard of care. Before being used as a treatment for COVID-19, there have been case reports of lopinavir-ritonavir-induced cardiac arrhythmias in patients on treatment for HIV-1. 7,8 As our patient had pre-existing IHD with first-degree atrioventricular block and prolonged interval QTc, he was at risk for cardiac-related side effects of lopinavir-ritonavir. Transient cardiac arrhythmias related to lopinavir/ritonavir in two patients with HIV infection	./cache/cord-293359-6iw7dnz6.txt	./txt/cord-293359-6iw7dnz6.txt