id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-293639-k96erjf1	Mugnai, Giacomo	Thoughts on Scientific Evidence in the COVID-19 Era	2020-06-24		.txt	text/plain	697	41	51	On the other hand, caution should be applied in generalizing preliminary (although potentially useful) observations as true scientific evidence. A few years ago, in Italy, several clinical trials were run by the National Health System on the "Di Bella" therapy for cancer, 2 more because of the pressure of public opinion than objective preclinical observations. 5 Hydroxychloroquine has recently been used as firstline therapy in COVID-19 patients and also proposed as a "preventive" agent, 6 but definitive evidence on its efficacy and safety (eg, QT prolongation) is missing, and, recently, the US Food and Drug Administration cautioned against hydroxychloroquine use in nonhospitalized COVID-19 patients, due to a number of side effects, including serious heart rhythm problems that can be life-threatening. Hydroxychloroquine or chloroquine for COVID-19: drug safety communication -FDA cautions against use outside of the hospital setting or a clinical trial due to risk of heart rhythm problems	./cache/cord-293639-k96erjf1.txt	./txt/cord-293639-k96erjf1.txt