id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294429-isivkz8b	Grifoni, Alba	Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals	2020-05-20		.txt	text/plain	10250	589	55	To test for the generation of SARS-CoV-2 CD4 + and CD8 + T cell responses following infection, we initially recruited 20 adult patients who had recovered from COVID-19 disease ( Table 1) . Initial definition and assessment of human antigen-specific SARS-CoV-2 T cell responses are best made with direct ex vivo T cell assays using broad-based epitope pools, such as MPs, and assays capable of detecting T cells of unknown cytokine polarization and functional attributes. Data from both the epitope MPs and protein peptide pool experiments can be interpreted in the context of previously reported T cell response immunodominance patterns observed for other coronaviruses, particularly the SARS and MERS viruses, which have been studied in humans, HLA-transgenic mice, wild-type mice and other species. (C) Correlation of SARS-CoV-2−specific CD4 + T cells detected using the epitope prediction approach (CD4_R MP) compared against the sum total of all antigen pools of overlapping peptides (excluding spike), run with samples from the same donors in two different experiment series.	./cache/cord-294429-isivkz8b.txt	./txt/cord-294429-isivkz8b.txt