id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295140-4gdlbc45	Yu, Pey‐Jen	Hypermetabolism and COVID‐19	2020-06-19		.txt	text/plain	964	72	49	METHOD: Resting energy expenditure (REE), carbon dioxide production (VCO2) and oxygen consumption (VO2) were measured by indirect calorimetry on seven critically ill patients with COVID‐19. As Acute Respiratory Distress Syndrome (ARDS) is associated with production of pro-inflammatory cytokines and induction of a hypermetabolic state, 2 we hypothesize that patients with COVID-19 may develop a hypermetabolic state which may be a major contributing factor to the extraordinary ventilatory and oxygenation demands in patients with COVID-19. 2, 3 The profoundly increased oxygen consumption and carbon dioxide production seen in our patient cohort as a result of their hypermetabolism may help explain the high failure rates for mechanical ventilation for patients with severe COVID-19. 6 We are currently involved in studies looking at the ideal target calories relative to the REE measured from indirect calorimetry in critically ill patients with COVID-19.	./cache/cord-295140-4gdlbc45.txt	./txt/cord-295140-4gdlbc45.txt