id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296232-6zj99nuw	Talukdar, Jayanta	Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19	2020-10-16		.txt	text/plain	7622	435	41	We present reports where ASX is shown to prevent against oxidative damage and attenuate exacerbation of the inflammatory responses by regulating signaling pathways like NF-ĸB, NLRP3 and JAK/STAT. Studies including human trials have shown that ASX effectively regulates immunity and disease etiology, suggesting its wide array of potential therapeutic and nutritional support in prevention and treatment of various pathogenic diseases and metabolic disorders, all of which have elements of oxidative stress and/or inflammation in the pathogenesis [8, 10, 17] . [9] found that the administration of ASX provides both preventive and curative anti-inflammatory effects against LPS-induced inflammation in the human gingival keratinocyte line NDUSD-1 by suppressing the production of IL-6 via inhibiting activation of the NF-ĸB signaling pathway. Evidence from these studies suggest that ASX is a potent antioxidant and a natural anti-inflammatory compound having efficient immunomodulatory action that exerts potential therapeutic benefits against oxidative and inflammation induced tissue damage.	./cache/cord-296232-6zj99nuw.txt	./txt/cord-296232-6zj99nuw.txt