id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297236-wnuvofwr	Zhang, Si	SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19	2020-09-04		.txt	text/plain	10404	646	50	SARS-CoV-2 and its Spike protein directly enhanced platelet activation such as platelet aggregation, PAC-1 binding, CD62P expression, α granule secretion, dense granule release, platelet spreading, and clot retraction in vitro, and thereby Spike protein enhanced thrombosis formation in wild-type mice transfused with hACE2 transgenic platelets, but this was not observed in animals transfused with wild-type platelets in vivo. However, similar to the results from the SARS-CoV-2 virus experiments, we were able to demonstrate that the Spike protein dose-dependently enhanced platelet aggregation and ATP release (Additional file 1: Online Figure 6 ). In addition, the Spike protein potentiated platelet aggregation and ATP release in response to agonists in vitro and enhanced thrombosis formation in vivo on hACE2 transgenic mice, while it had no effect on wild-type mice ( Fig. 6c and Additional file 1: Online Figure 8 ).	./cache/cord-297236-wnuvofwr.txt	./txt/cord-297236-wnuvofwr.txt