id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299116-1agfnjvq	Bunders, Madeleine	Implications of sex differences in immunity for SARS-CoV-2 pathogenesis and design of therapeutic interventions	2020-08-17		.txt	text/plain	6250	333	45	Emerging knowledge on the basic biological pathways that underlie differences in immune responses between women and men needs to be incorporated into research efforts on SARS-CoV-2 pathogenesis and pathology to identify targets for therapeutic interventions aimed at enhancing antiviral immune function and lung airway resilience while reducing pathogenic inflammation in COVID-19. The current Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) pandemic highlights the clinical consequences of these sex differences in antiviral immunity and tissue resilience Scully et al., 2020) , with in particular older men suffering from severe Coronavirus disease 2019 (COVID-19) and experiencing higher case mortality rates (Docherty et al., 2020; Grasselli et al., 2020; Jin et al., 2020; Salje et al., 2020) . In the following, we will address the different stages of SARS-CoV-2 pathogenesis, including viral entry and sensing, induction of antiviral immune responses and inflammation, and immune-mediated tissue-repair, in the context of critical differences in immune responses that exist between the sexes and contribute to the male-bias in development of severe COVID-19.	./cache/cord-299116-1agfnjvq.txt	./txt/cord-299116-1agfnjvq.txt