id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299882-ee5wathm	Hsiehchen, David	Deficiencies in the designs and interventions of COVID-19 clinical trials	2020-07-04		.txt	text/plain	1166	65	38	[1] [2] [3] [4] Particularly concerning is that the dearth of high-quality medical evidence has contributed to a lack of confidence in existing guidelines on COVID-19 therapies, the off-label use of unproven therapies by patients and clinicians, and predatory behaviors exploiting the lack of strong scientific rationale for many tested interventions. 4, 6 We assessed the strength of preclinical evidence supporting the most popular interventional drugs purported to have direct anti-viral activity by examining all related PubMed entries (Supplementary Figure 1D) . Geographic differences in trial characteristics, the poor alignment between trial numbers and COVID-19 disease burden, and lack of international collaborations suggest that better integration of clinical research efforts is warranted to combat a global public health crisis. PubMed entries associated with the indicated intervention are shown, including publications describing experiments that directly assessed In vitro or in vivo anti-viral activity	./cache/cord-299882-ee5wathm.txt	./txt/cord-299882-ee5wathm.txt