id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-300805-apli48ih	Augoustides, John G.	The Renin-Angiotensin-Aldosterone System in Coronavirus Infection – current considerations during the pandemic	2020-04-16		.txt	text/plain	1466	104	42	[1] [2] [3] The pharmacologic modulation of this system with agents such as angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBS) has resulted in major clinical benefits in the medical management of hypertension and heart failure. [4] [5] The severe acute respiratory syndrome coronavirus-2 infects human cells such as alveolar endothelium in the lung by binding to the membrane receptor, angiotensin-converting enzyme 2 (ACE2). Given that these RAAS inhibitors are common therapies for hypertension and that they may up-regulate the expression of ACE2, the clinical concern has been formulated that therapy with these agents may increase the risk and severity of coronavirus infection. Further trials will likely focus on the current evidence gaps related to this question in severe COVID-19 including mechanisms, the prevalence of RAAS inhibitors, and careful correlation of this prevalence with clinical outcomes.	./cache/cord-300805-apli48ih.txt	./txt/cord-300805-apli48ih.txt