id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302115-r39ser2c	Matricardi, Paolo Maria	The first, holistic immunological model of COVID‐19: implications for prevention, diagnosis, and public health measures	2020-05-02		.txt	text/plain	3738	237	46	We propose here the first model, explaining how the outcome of first, crucial 10‐15 days after infection, hangs on the balance between the cumulative dose of viral exposure and the efficacy of the local innate immune response (natural IgA and IgM antibodies, Mannose Binding Lectin ). The delayed and strong adaptive immune response (high affinity IgM and IgG antibodies) that follows, causes severe inflammation and triggers mediator cascades (complement, coagulation, and cytokine storm) leading to complications often requiring intensive therapy and being, in some patients, fatal. All rights reserved We focused on humoral components and, in particular on natural antibodies and MBL, to ascertain whether these players of the innate immunity fit all the epidemiological and clinical pre-conditions presented in the last three months by SARS-CoV-2. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for Accepted Article This article is protected by copyright.	./cache/cord-302115-r39ser2c.txt	./txt/cord-302115-r39ser2c.txt