id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302442-jhio7mrl	Chrzanowski, Wojciech	Can Stem Cells Beat COVID-19: Advancing Stem Cells and Extracellular Vesicles Toward Mainstream Medicine for Lung Injuries Associated With SARS-CoV-2 Infections	2020-05-26		.txt	text/plain	4158	180	38	Stem cell therapies and, more recently, their secreted extracellular vesicles (EVs), are emerging as new promising treatments, which could attenuate inflammation but also regenerate the lung damage caused by COVID-19. In this review article, we outline the mechanisms of cytokine storm and lung damage caused by SARS-CoV-2 virus leading to COVID-19 disease and how mesenchymal stem cells (MSCs) and their secreted EVs can be utilized to tackle this damage by harnessing their regenerative properties, which gives them potential enhanced clinical utility compared to other investigated pharmacological treatments. The safety profile and efficacy of MSCs are well-established based on the results from a number of completed clinical studies investigating the therapeutic potential of these therapies in lung diseases such as ARDS (Matthay et al., 2019; and bronchopulmonary dysplasia (Namba, 2019) , cardiovascular diseases (Kim et al., 2015; Suvakov et al., 2020) , diabetes (Thakkar et al., 2015; Cho et al., 2018) , and spinal cord injury (Xu and Yang, 2019) .	./cache/cord-302442-jhio7mrl.txt	./txt/cord-302442-jhio7mrl.txt