id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302576-fv2ib5vc	Barisione, Emanuela	Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems	2020-09-28		.txt	text/plain	5448	238	37	This study uses an innovative cryobiopsy approach for the post-mortem sampling of lung tissues from COVID-19 patients demonstrating the progression of fibrosis in time and correlation with computed tomography features. The main findings of this study include the following: (1) the identification of a chronological evolution of lesions from an early exudative phase with hyaline membranes to a mid-phase characterized by intra-alveolar fibrinous exudate and early fibroblastic interstitial fibrosis to a late phase with alveolar obliteration by fibrosis and possible micro-honeycombing; (2) mild degree of inflammatory infiltrates; and (3) correlation of histologic patterns with lung CT alterations. Immunohistochemistry for SARS-CoV-2 nucleocapsid protein also showed modification during disease progression as intense immunostaining was seen in early exudative phase Fig. 4 Histology and radiology of late/organizing phase of DAD pattern: aspects of progressive derangement/obliteration of alveolar structure by interstitial fibroblast proliferation.	./cache/cord-302576-fv2ib5vc.txt	./txt/cord-302576-fv2ib5vc.txt