id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302947-flgwxc57	Kipshidze, Nicholas	Targeted, Site-Specific, Delivery Vehicles of Therapeutics for COVID-19 Patients. Brief Review	2020-09-16		.txt	text/plain	2142	121	34	In this review we have outlined various target directed approaches which include microbubbles, extracellular vesicles including exosomes, adenosine nanoparticles, novel bio-objects, direct aerosol targeted pulmonary delivery and catheter-based drug delivery with reference to their relative effectiveness for the specific lesions. 3, 4 Considering that COVID-19 primarily affects the lungs in patients with ARDS, 5 we propose a targeted drug delivery strategy using different types of drug delivery vehicles including microbubbles, extracellular vesicles (EV), nanoparticle drug carriers, liposomes, viral vectors, perfluorocarbon droplets, catheter-based and aerosol-based approaches. Microbubbles specifically have shown to adhere to sites of damaged vascular endothelium and thus may be a method of systemically targeting delivery of therapeutics to damaged lungs with SARS-CoV-2. Further investigations through well-designed, timely clinical studies for targeted site-specific therapy will demonstrate evidence toward the best carriers, delivery methods, and approach (i.e. combination systemic and local delivery versus stand-alone).	./cache/cord-302947-flgwxc57.txt	./txt/cord-302947-flgwxc57.txt