id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303237-xvba5mqq	Wang, L.-Y.	Genetic Profiles in Pharmacogenes Indicate Personalized Drug Therapy for COVID-19	2020-03-30		.txt	text/plain	4453	295	56	Racial discrepancy of common nonsynonymous mutations was found in pharmacogenes including: VDR, ITPA, G6PD, CYP3A4 and ABCB1 which related to DCTs including ribavirin, -interferon, chloroquine and lopinavir. In addition to this mutation, we further identified 10 common non-synonymous polymorphisms in all populations ( Figure 4F ). Thus, we analyzed the expression of virus or drug target genes in different lung cells ( Figure 5A ). https://doi.org/10.1101/2020.03.23.20041350 doi: medRxiv preprint drug metabolic enzymes in different liver cells ( Figure 6A ). Due to the activity difference exists among populations, the genotypes of important alleles in CYP450 family should be detected after diagnosis, then treatment strategies for these drugs can be suggested in these patients. pharmacogenes in patients can hardly be detected in single cell resolution during COVID-19 treatment, although the expression level of these genes can be associated with drug efficacy or toxicity.	./cache/cord-303237-xvba5mqq.txt	./txt/cord-303237-xvba5mqq.txt