id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303585-8py6joh6	Verma, Surjeet	Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)	2020-09-25		.txt	text/plain	10884	562	50	The objective of this review was to collate information regarding the potential of plants and natural products to inhibit coronavirus and targets associated with infection in humans and to highlight known drugs, which may have potential activity against SARS-CoV-2. Finally, this review discusses the potential use of Southern African medicinal plants, which have traditionally been used for the treatment of symptoms related to respiratory viral infections, and influenza, to inhibit SARS-CoV-2. The selective index (SI) values of compounds 1-6 were found to be 58, >510, 111, 193, 180 , and >667, respectively, indicating that these plants were able to inhibit viral replication without having a cytotoxic effect on the host cells. A chalcone, xanthoangelol E (8), isolated from the ethanolic leaf extract of Angelica keiskei (Miq.) Koidz., showed inhibitory activity against SARS-CoV 3CL pro and a papain-like protease (PL pro ) with IC 50 values of 11.4 and 1.2 µM, respectively, using cell-free assays.	./cache/cord-303585-8py6joh6.txt	./txt/cord-303585-8py6joh6.txt