id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303811-vr5nao8w	Binson, Guillaume	Preparation and physicochemical stability of 50 mg/ml hydroxychloroquine oral suspension in Syrspend pH4 dry	2020-10-16		.txt	text/plain	3055	158	41	Finally, use of the proposed oral suspension provides a reliable solution to perform safe and accurate administration of hydroxychloroquine to patients with SARS-CoV-2 infection. Matrix effect was assessed comparing calibration curves prepared in water versus calibration curves obtained using Syrspend® SF PH4 Dry. Dilution was performed using water solution containing 0.1% of the suspending vehicle in order to mimic the exact composition of samples obtained after dilution of the oral suspensions before HPLC-UV analysis. According to the doses proposed for COVID-19 patients (from 100 mg to 600 mg per dose) we chose to prepare oral liquid dosage forms at a target concentration (50 mg/mL) higher than the formulations proposed by McHenry et al., thereby reducing by a factor of two the volume of administration required. In light of all this, the compounded oral liquid formulation proposed in this study provides an appropriate and easy to use dosage form for oral hydroxychloroquine treatment, enabling safe and accurate hydroxychloroquine dose administration to patients with SARS-CoV-2 infection.	./cache/cord-303811-vr5nao8w.txt	./txt/cord-303811-vr5nao8w.txt