id author title date pages extension mime words sentences flesch summary cache txt cord-303819-w1785lap Cortegiani, Andrea Update I. A systematic review on the efficacy and safety of chloroquine/hydroxychloroquine for COVID-19 2020-07-11 .txt text/plain 3475 202 54 MATERIALS AND METHODS: MEDLINE, PubMed, EMBASE and two pre-print repositories (bioRxiv, medRxiv) were searched from inception to 8th June 2020 for RCTs and nonrandomized studies (retrospective and prospective, including single-arm, studies) addressing the use of CQ/HCQ in any dose or combination for COVID-19. Low and moderate risk of bias studies suggest that treatment of hospitalized COVID-19 with CQ/HCQ may not reduce risk of death, compared to standard care. Journal Pre-proof PICO question: The current review covers studies comparing adult patients with or at risk of COVID-19 (P) who had been administered CQ or related formulations, alone or in combination with other drugs (I) to those given standard care or other regimens or drugs (C). Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19) Assessment of QT Intervals in a Case Series of Patients With Coronavirus Disease 2019 (COVID-19) Infection Treated With Hydroxychloroquine Alone or in Combination With Azithromycin in an Intensive Care Unit ./cache/cord-303819-w1785lap.txt ./txt/cord-303819-w1785lap.txt