id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304035-s9tkyuso	Inal, Jameel	Biological Factors Linking ApoE ε4 Variant and Severe COVID-19	2020-10-02		.txt	text/plain	958	49	46	This included an erudite analysis of raised levels of Lp(a) in certain ethnic groups and association with higher frequency of ApoE4 genotypes and risk of severe COVID-19. Compared with the more common ApoE ε3ε3 genotype, the risk of severe COVID-19 for people carrying two ApoE ε4 alleles was doubled (OR = 2.31), including people who had neither developed Alzheimer's disease (AD) (as for the 5.13% COVID-19positive participants) nor cardiovascular disease (CVD), and for whom two copies of ApoE ε4 also carried increased risk. Besides raised Lp(a), as highlighted by Moriarty et al., other biological effects may link the ApoE ε4ε4 genotype to severe COVID-19. In continuing to explore the possible association of the ApoE ε4 allele with COVID-19, it is useful to remember that ApoE is also linked to susceptibility to infection by viruses [8] (as well as bacteria and parasites, including secondary infection), for example, ApoE4 increasing HIV-1 infection, two copies of ε4 aiding accelerated disease development [8] .	./cache/cord-304035-s9tkyuso.txt	./txt/cord-304035-s9tkyuso.txt