id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-304656-v0fyb161	Balayla, J.	Prevalence Threshold and Temporal Interpretation of Screening Tests: The Example of the SARS-CoV-2 (COVID-19) Pandemic	2020-05-22		.txt	text/plain	2130	137	56	In consequence, there is an inflection point of maximum curvature in the screening curve defined as a function of the sensitivity and specificity beyond which the rate of change of a test's PPV declines sharply relative to disease prevalence. Understanding where this prevalence point lies in the curve has important implications for the interpretation of test results, the administration of healthcare systems, the implementation of public health measures, and in cases of pandemics like SARS-CoV-2, the functioning of society at large. To illustrate the methods herein described, we provide the example of the screening strategies used in the SARS-CoV-2 (COVID-19) pandemic, and calculate the prevalence threshold statistic of different tests available today. In contrast to RT-PCR screening, COVID-19 testing with serology can 150 delineate immune individuals at a prevalence threshold as low as 4.3%.	./cache/cord-304656-v0fyb161.txt	./txt/cord-304656-v0fyb161.txt