id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305089-y5cdqlze	González-García, Andrés	Successful treatment of severe COVID-19 with subcutaneous anakinra as a sole treatment	2020-06-22		.txt	text/plain	1265	62	40	After an initial viral phase with fever, coughing and mild upper respiratory tract symptoms, some COVID-19 patients may experience a hyperinflammatory phase manifested with biological changes of a cytokine storm syndrome (with increased levels of ferritin and CRP), which are similar to those observed after chimeric antigen receptor (CAR) Tcell therapy and in haemophagocytic lymphohistiocytosis (HLH), as well as in macrophage activation syndrome (MAS), a secondary HLH form, classically associated with autoimmune or inflammatory conditions [2] . IL-1 may also play a determinant role in the cytokine storm syndrome of COVID-19 by activating the inflammasome after the interaction of the SARS-CoV-2 with specific Toll-like receptors, leading to a final uncontrolled production of active mature IL-1b, a mediator known to be involved in fever and inflammatory and fibrotic pulmonary changes [6] .	./cache/cord-305089-y5cdqlze.txt	./txt/cord-305089-y5cdqlze.txt