id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-306414-2dv3qced	Gutierrez, Lucas	Deciphering the TCR Repertoire to Solve the COVID-19 Mystery	2020-06-20		.txt	text/plain	6993	368	42	Advances in sequencing technologies and single-cell immune profiling can be leveraged to monitor adaptive immune responses in COVID-19 patients and guide future SARS-CoV-2 immunotherapy and biomarker development. Whether the aged and less diverse TCR repertoire impacts the ability to generate a sufficiently robust T cell response against SARS-CoV-2 in older patients remains to be studied. The development of faster and cheaper sequencing technologies, augmented by the advances in computational tools, support the feasibility of using TCR analyses not only to track SARS-CoV-2specific T cell expansion post-COVID-19 infection or in the course of treating patients with COVID-19, but also to establish certain features of the TCR repertoire architecture as predictive biomarkers for patients' clinical outcome. Thus, a comprehensive characterization of the dynamics and composition of the TCR repertoires to SARS-CoV-2 infection can largely contribute to the evolving understanding of the functional and mechanistic involvement of the adaptive immune cell response and potentially guide the design of effective treatment.	./cache/cord-306414-2dv3qced.txt	./txt/cord-306414-2dv3qced.txt