id author title date pages extension mime words sentences flesch summary cache txt cord-307284-w693a2rm Flament, H. Outcome of SARS-CoV-2 infection linked to MAIT cell activation and cytotoxicity: evidence for an IL-18 dependent mechanism 2020-09-02 .txt text/plain 5365 428 60 . https://doi.org/10.1101/2020.08.31.20185082 doi: medRxiv preprint Introduction: 65 The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the etiologic agent 83 and chronic viral infections, MAIT cell blood frequency is reduced while expression of HLA-DR, 84 PD-1, CD38 and CD69 is upregulated 18-20, [22] [23] [24] . 98 We first began our study of immune cells in SARS-CoV-2 infection by analyzing the frequency 99 and phenotype of lymphocytes in blood samples from COVID-19 patients as well as (age-100 matched BMI-matched) non-infected donors (Fig. 1a) . Blood MAIT cells also displayed a significant increase of the NK cell-associated 129 activation CD56 + marker compared to controls, that was highest in ICU patients (Fig. 2a) . 179 Taken together, these data suggest that inflammatory processes in SARS-CoV-2-infected 180 patients involve concomitant activation of MAIT cells with other innate-immune cells 181 associated with loss of these populations' frequencies in blood. ./cache/cord-307284-w693a2rm.txt ./txt/cord-307284-w693a2rm.txt