id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-307406-59yh48tt	de Loyola, Mariana Braccialli	Alpha‐1‐antitrypsin: A possible host protective factor against Covid‐19	2020-08-26		.txt	text/plain	5739	408	47	2, 3 A1AT is an inhibitor of SARS-CoV-2 infection and two of the most important proteases in the pathophysiology of Covid-19: the transmembrane serine protease 2 (TMPRSS2) and the disintegrin and metalloproteinase 17 (ADAM17), as was well as an inhibitor of inflammatory molecules, such as IL-8, TNF-α, and neutrophil elastase. [4] [5] [6] Moreover, recent data indicate that lower IL-6:A1AT levels are related to worse prognosis in This review addresses the interplay between A1AT, TMPRSS2, ADAM17, and inflammatory molecules during SARS-CoV-2 infection with the aim of identifying new avenues for effective treatments against Covid-19. In order to achieve a more comprehensive understanding of A1AT in Covid-19, is important to address the following concerns: The evidence presented in this review highlights the relevance of the A1AT as a host protective factor, which can inhibit the TMPRSS2-mediated SARS-CoV-2 infection, modulate the deleterious effect of ADAM17 activation and the activity of inflammatory molecules, such as IL-8, TNF-α, and neutrophil elastase.	./cache/cord-307406-59yh48tt.txt	./txt/cord-307406-59yh48tt.txt