id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308303-tgpqnoq2	Liu, X.	Heparin-induced thrombocytopenia is associated with a high risk of mortality in critical COVID-19 patients receiving heparin-involved treatment	2020-04-28		.txt	text/plain	4572	261	49	Medical records, including demographic, platelet counts, heparin-involved treatments, heparin-induced thrombocytopenia-(HIT) related laboratory tests, and fatal outcomes of COVID-19 patients were analyzed and compared between survivors and nonsurvivors. These results suggested that severe thrombocytopenia with progressively platelet count decrease occurred in most critical COVID-19 patients before a fatal outcome. 26 Although the platelet activation assay was not performed because of the limited capacity of Huoshenshan Hospital, current results still strongly suggested that HIT or spontaneous HIT, induced by the virus or a secondary bacterial infection, may occur in COVID-19, which would be significantly boosted and aggravated by further heparin exposure with a high dose, thereby resulting in a fatal outcome. Notably, HIT antibodies and a progressive decrease in PLT were also detected in heparin-naïve patients (i.e., before CRRT or other heparin exposure), even in non-ICU patients (figure 4B), indicating the occurrence of spontaneous HIT in COVID-19 patients, which probably results from virus itself or a secondary bacterial infection, such as PF4-conjugated Staphylococcus aureus or Escherichia coli, or severe tissue damage.	./cache/cord-308303-tgpqnoq2.txt	./txt/cord-308303-tgpqnoq2.txt