id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308358-2bap7iih	Friedland, Robert P	The role for the metagenome in the pathogenesis of COVID-19	2020-10-07		.txt	text/plain	1126	57	39	A common factor associated with aging and other COVID-19 risk factors is the dysbiosis of gut microbiota and resulting low grade inflammation with loss of epithelial barrier function [5] . Germ free animals have defective immune systems and the gut microbiota influences pathogen dissemination, inflammation, organ damage and mortality in murine pneumonia [9] . Changes in diet with aging may well influence short chain fatty acid production, affecting immune homeostasis, barrier function and severity of COVID-19. However, in cases of severe disease of COVID-19, it is the innate response and not the unregulated adaptive immune response via T cells that results in morbidity and death. The influence of the microbiota on immune processes in COVID19 infection may be assessed with metagenomic analysis of nasal, oral and intestinal communities, as well as metabolomics. Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals	./cache/cord-308358-2bap7iih.txt	./txt/cord-308358-2bap7iih.txt