id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308545-5n55yl2s	Verscheijden, Laurens F. M.	Chloroquine Dosing Recommendations for Pediatric COVID‐19 Supported by Modeling and Simulation	2020-05-21		.txt	text/plain	2698	165	54	4, 5 The Dutch Centre for Infectious Disease Control (CIDC) recommends a total cumulative dose of 3,300 mg CHQ base (44 mg/kg for a 75 kg adult), reducing the risk of adverse events by limiting treatment to 5 days. As CHQ is licensed for use in children with malaria, 8 it may seem rational to use the World Health Organization (WHO) recommended antimalarial dose to treat COVID-19 infected pediatric patients (25 mg/kg given over 3 days). In fact, the current pediatric WHO dose may even be questionable for the treatment of malaria, as recent studies show that older infants and children may need a higher mg/kg dose to reach similar drug concentrations as adults. These doses support previous pharmacokinetic (PK) studies in pediatric patients with malaria showing a need for higher mg/kg doses, as compared with adults, to reach similar plasma exposures in children 6 months to 12 years.	./cache/cord-308545-5n55yl2s.txt	./txt/cord-308545-5n55yl2s.txt