id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308740-06jr58kz	Lazaridis, Charalampos	Involvement of Cardiovascular System As The Critical Point in Coronavirus Disease 2019 (COVID-19) Prognosis and Recovery	2020-06-10		.txt	text/plain	2536	173	42	All cases were linked to a seafood market in the same city 2 and were confirmed to be associated with a novel RNA betacoronavirus, which was later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3,4 . A recent study in patients with heart failure found that circulating levels of ACE2 were higher in men than in women, suggesting increased ACE2 tissue expression which could contribute to susceptibility to SARS-CoV-2 infection and disease progress 49 . Remarkably, severe COVID-19 has been associated with hypokalemia and higher blood pressure, supporting suggestions of decreased ACE2 function and augmented levels of angiotensin II after SARS-CoV-2 infection 96 . The participation of ACE2 in the pathogenesis of COVID-19, acting as a cell receptor for SARS-CoV-2 13 has caused increasing concern about the role of antihypertensive therapy with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II Chloroquine, an antimalarial agent with known anti-viral effects 141 Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan	./cache/cord-308740-06jr58kz.txt	./txt/cord-308740-06jr58kz.txt