id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309128-gmraihg6	Yanai, Hidekatsu	A Significance of High Prevalence of Diabetes and Hypertension in Severe COVID-19 Patients	2020-06-04		.txt	text/plain	1428	87	48	It remains unknown why the prevalence of diabetes and hypertension is high in COVID-19 patients and why such diseases can be risk for severe COVID-19 including death. Half of studies showed a statistically significantly higher prevalence of diabetes in severe patients than in non-severe patients. Five of 12 studies showed a statistically significantly higher prevalence of hypertension in severe patients than in non-severe patients. Since hypertension is one of the most significant risk factors for severe disease and mortality in COVID-19, and angiotensin-converting enzyme (ACE) 2 is the entry receptor of SARS-CoV-2 [14, 15] , the effects of ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in COVID-19 patients have received much focus. Four of 11 studies showed a statistically significantly higher prevalence of CVD in severe patients than in non-severe patients. A very recent article reported the development of Kawasaki disease in COVID-19 patient [23] , supporting an association between endothelial injury and severe COVID-19.	./cache/cord-309128-gmraihg6.txt	./txt/cord-309128-gmraihg6.txt