id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309147-c3ikb81g	Nadeem, Muhammad Shahid	Origin, Potential Therapeutic Targets and Treatment for Coronavirus Disease (COVID-19)	2020-04-22		.txt	text/plain	4984	315	51	According to available information, SARS-CoV-2 is inferred to be a recombinant virus that originated from bats and was transmitted to humans, possibly using the pangolin as the intermediate host. The interaction of the SARS-CoV-2 spike protein with the human ACE2 (angiotensin-converting enzyme 2) receptor, and its subsequent cleavage by serine protease and fusion, are the main events in the pathophysiology. The recent reports have suggested that SARS-CoV-2 is a modified coronavirus of bat origin [22, 32] , which came to humans as a result of zoonotic transmission [33, 34] . The receptor-binding domain (RBD) of pangolin-CoV has only a one amino acid difference with that of SARS-CoV-2; the infected pangolins exhibit pathological symptoms similar to humans suffering from COVID-19, and their blood circulating antibodies can react with the spike protein of SARS-CoV-2 [35, 36] . Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): The epidemic and the challenges	./cache/cord-309147-c3ikb81g.txt	./txt/cord-309147-c3ikb81g.txt