id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309214-v2iqgjc4	Nougier, Christophe	Hypofibrinolytic state and high thrombin generation may play a major role in sars‐cov2 associated thrombosis	2020-07-15		.txt	text/plain	2628	157	41	RESULTS AND CONCLUSIONS: We observed two key findings: a high thrombin generation capacity which remained within normal values despite heparin therapy and a hypofibrinolysis mainly associated with increased PAI‐1 levels. The aim of the present study was to assess thrombin generation capacity and fibrinolytic activity of patients hospitalized for Covid-19 All patients received supportive management of the most common complications of severe COVID-19: pneumonia, hypoxemic respiratory failure, sepsis, cardiomyopathy and arrhythmia, acute kidney injury, complications from prolonged hospitalization, including secondary bacterial infections, gastrointestinal bleeding, critical illness polyneuropathy and appropriate thrombopropylaxis with LMWH (enoxaparin 40mg OD if 50-100kg and 40mg BD if >100kg or fibrinogen>8g/L or D-dimer>3000 ng/mL) or subcutaneous unfractionated heparin (5000 UI BD) according to their renal status. Our data clearly show that the balance between coagulation and fibrinolysis is lost in patients with infection, who present with a significant hypercoagulability associated with hypofibrinolysis associated with high PAI-1 and increased TAFI activation. In 17 ICU-Covid-19 patients without thrombosis, a much less effective fibrinolysis with a Ly30 of 37±35% was observed, which was in accordance with high PAI-1 plasma levels and elevated TAFI activation.	./cache/cord-309214-v2iqgjc4.txt	./txt/cord-309214-v2iqgjc4.txt