id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-309864-yzb3si3w	Smeda, Marta	Endothelial barrier integrity in COVID-19-dependent hyperinflammation: does the protective facet of platelet function matter?	2020-08-01		.txt	text/plain	1583	85	25	5 Here we suggest that the severity of COVID-19, increasing with patient age and/or the presence of cardiovascular comorbidities, might also be associated with the impairment of platelet-dependent mechanisms preserving the integrity of the endothelial barrier. Indeed, platelet-dependent endothelium-protective mechanisms play an important role in acute and chronic inflammatory conditions, 6 and might safeguard the endothelial barrier of the pulmonary microcirculation alongside COVID-19-induced hyperinflammation. Based on the evidence supporting platelet-dependent mechanisms protecting endothelial barrier integrity in inflammation, it is tempting to speculate that increased microcirculation permeability associated with thrombocytopenia or prolonged use of antiplatelet agents and preexistising endothelial dysfunction of cardiovascular diseases may contribute to the increased severity of COVID-19-related ARDS. Therefore, it is fundamental to better understand how to dissociate the prothrombotic/proinflammatory mechanisms of platelets from those that protect against vascular leakage so as to be able to strengthen the latter pharmacologically to safeguard the endothelial barrier in the pulmonary microcirculation in patients with acute inflammation at high risk of a severe course of COVID-19 disease.	./cache/cord-309864-yzb3si3w.txt	./txt/cord-309864-yzb3si3w.txt