id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310740-7dong29x	Alkeridy, Walid A.	Reply to: Neurological, Cognitive and Behavioral Disorders During COVID‐19: The Nitric Oxide Track	2020-06-24		.txt	text/plain	622	55	36	Possibly, the mechanism proposed by Annweiler et al 1 pertaining to the nitric oxide track could explain the rapid improvement in our patient's cognition following just a brief period of supportive management. [3] [4] [5] In fact, nitric oxide has long been implicated in the pathogenesis of delirium and cognitive impairment. 6, 7 Whether the nitric oxide track will prove to have a central role in the acute manifestations of COVID-19related cognitive impairment remains to be seen. 7 We propose that the underlying mechanism of COVID-19 central nervous system manifestation or delirium depends on the interaction between SARS-CoV-2 activated molecular pathways and the individual related factors, including age, COVID-19 severity, individual's underlying genetic susceptibility, vascular risk factors, premorbid cognitive function, use of certain medication, and comorbidities. 8 We propose possible mechanisms of COVID-19related cognitive dysfunction (Table 1) , which could help researchers in studying the specific pathways associated with each possible mechanism. cognitive and behavioral disorders during COVID-19: the nitric oxide track	./cache/cord-310740-7dong29x.txt	./txt/cord-310740-7dong29x.txt