id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310776-4iqu18gi	Supady, Alexander	Extracorporeal cytokine adsorption as an alternative to pharmacological inhibition of IL-6 in COVID-19	2020-08-20		.txt	text/plain	546	35	41	Following initial reports describing Interleukin-6 (IL-6) as a predictive factor for a negative outcome, extracorporeal cytokine adsorption was discussed as a possible treatment option for severe COVID-19 cases. A major advantage of extracorporeal cytokine adsorption over the other therapeutic approaches discussed in this debate is that it does not selectively block a specific receptor or signal transduction cascade, but it rather reduces particularly elevated concentrations of various inflammatory mediators such as interleukins, TNF-α, and also interferons; these factors have both pro-and anti-inflammatory functions. These two aspects may be particularly relevant, e.g., in the case of bacterial superinfection in severe COVID-19 when an adequate immune response is required. Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients	./cache/cord-310776-4iqu18gi.txt	./txt/cord-310776-4iqu18gi.txt