id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310999-6xef9z2w	Chen, Yiting	In the big picture of COVID-19 pandemic: what can sleep do	2020-06-10		.txt	text/plain	475	39	60	title: In the big picture of COVID-19 pandemic: what can sleep do In the big picture of COVID-19 pandemic: what can sleep do Q3 The world is grappling with the coronavirus disease 2019 (COVID-19) pandemic, however, currently there is no effective antivirals or vaccines for it. A newly published review posited that ACE2 might exhibit circadian rhythm due to indirect effects of circadian rhythm changes in the renin angiotensin system, indicating the possible link of circadian rhythm to COVID-19 susceptibility [2] . Additionally, when exposed to COVID-19 infection, a series of pro-inflammatory cytokines were activated, increasing the risk of developing a cytokine storm [3] . a sleep-inducing hormone, is associated with the reduction of cytokines (eg, IL-6 and TNF-a); thus, melatonin is anti-inflammatory and immune enhancing, which has been suggested as an adjuvant therapy for COVID-19 [3] . COVID-19: melatonin as a potential adjuvant treatment In the big picture of COVID-19 pandemic: what can sleep do	./cache/cord-310999-6xef9z2w.txt	./txt/cord-310999-6xef9z2w.txt