id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311029-x0lk4110	Palermo, Sara	Covid-19 Pandemic: Maximizing Future Vaccination Treatments Considering Aging and Frailty	2020-09-18		.txt	text/plain	6411	353	40	For that reason, the Clinical Trials Regulation (EC) No. 536/2014 states that "in order to improve treatments available for vulnerable groups such as frail or older people, people suffering from multiple chronic conditions, and people affected by mental health disorders, medicinal products which are likely to be of significant clinical value should be fully and appropriately studied for their effects in these specific groups, including as regards requirements related to their specific characteristics and the protection of the health and well-being of subjects belonging to these groups." Indeed, EMA develops scientific guidelines to help medicine developers address the specific requirements of older people in their medicine development programs, including in the design and conduct of clinical trials. EMA disclosed a reflection paper on "Physical frailty: instruments for baseline characterization of older populations in clinical trials" (7), actively recognizing the importance of considering the various types of aging when experimenting and developing new pharmacological treatments.	./cache/cord-311029-x0lk4110.txt	./txt/cord-311029-x0lk4110.txt