id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312558-w2vjuidm	Gambardella, J.	Exosomal microRNAs Drive Thrombosis in COVID-19	2020-06-18		.txt	text/plain	901	61	50	To test the hypothesis that exosomal miRNAs are a key determinant of thrombosis in COVID-19, we enrolled 26 patients positive for COVID-19 admitted to the Infectious Disease Departments of University of Naples "Vanvitelli" and San Sebastiano Caserta Hospital (Italy). Equally important, miR-424 has been associated with hypercoagulability whereas low levels of miR-103a have been observed in deep vein thrombosis (5, 12) , although precise mechanisms have not been fully defined for these miRNAs. To our knowledge, this is the first study showing a functional contribution of exosomal noncoding RNA in COVID19. Limitations of our study include the relatively small population and the fact that we did not determine the exact source of exosomes; nevertheless, since endothelial dysfunction has been shown to be a prominent feature of COVID-19 and to contribute to the pro-thrombotic and pro-inflammatory state of the vasculature (2), we speculate that a main source could be represented by endothelial cells, which express these miRNAs in normal conditions (5).	./cache/cord-312558-w2vjuidm.txt	./txt/cord-312558-w2vjuidm.txt