id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312684-3i2r2ahr	Iba, Toshiaki	Coagulopathy in COVID‐19	2020-06-18		.txt	text/plain	3630	213	39	For example, the coronavirus that caused severe acute respiratory syndrome (SARS) in 2002 (SARS-CoV-1) were reported to be associated with thrombocytopenia (55%), thrombocytosis (49%), and prolonged activated partial thromboplastin time (aPTT) (63%), but the incidence of bleeding was not high [5, 6] . In this respect, Chinese experts noted that in severe cases, patients can develop acute respiratory distress syndrome (ARDS), with coagulation predominant-type coagulopathy [9] . The excess production of proinflammatory cytokines, increased levels of damage-associated molecular patterns (DAMPs), the stimulation of cell-death mechanisms and vascular endothelial damage are the major causes of coagulation disorder in any severe infection (Fig. 1) . The major targets of the SARS-CoV-2 are the lung epithelial cell, lymphocyte, and the vascular endothelial cell, and these findings can explain that the clinical presentation of severe COVID-19 is characterized by ARDS, shock, and coagulopathy [12, 47] .	./cache/cord-312684-3i2r2ahr.txt	./txt/cord-312684-3i2r2ahr.txt