id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314109-wb45naw2	Maiese, Kenneth	The Mechanistic Target of Rapamycin (mTOR): Novel Considerations as an Antiviral Treatment	2020-06-17		.txt	text/plain	4134	226	35	One such avenue that may prove to be exceedingly fruitful and offer exciting potential as new antiviral therapy involves the mechanistic target of rapamycin (mTOR) and its associated pathways of mTOR Complex 1 (mTORC1), mTOR Complex 2 (mTORC2), and AMP activated protein kinase (AMPK). Recent work has shown that mTOR pathways in conjunction with AMPK may offer valuable targets to control cell injury, oxidative stress, mitochondrial dysfunction, and the onset of hyperinflammation, a significant disability associated with COVID-19. Considering that one of the mechanisms that can lead to severe disability and death during infection with SARS-CoV-2 is an exaggerated activation of the host's immune system that results in systemic hyperinflammation with the elevation of multiple pro-inflammatory cytokines, it is interesting to note that mTOR pathways have been tied to immune system modulation [40, 54, 55] . • The mechanistic target of rapamycin (mTOR) and its associated pathways with mTOR Complex 1 (mTORC1), mTOR Complex 2 (mTORC2), and AMP activated protein kinase (AMPK) offer new avenues of opportunity for the development of innovative antiviral treatment strategies.	./cache/cord-314109-wb45naw2.txt	./txt/cord-314109-wb45naw2.txt