id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314171-431buxxr	Dariya, Begum	Understanding novel COVID-19: its impact on organ failure and risk assessment for diabetic and cancer patients	2020-05-06		.txt	text/plain	6892	421	51	In this review article, we have presented the effect of SARS-CoV-2 infection in comorbid patients and discussed organ failure caused by this virus. The mRNA and protein ACE2 expression levels are higher in these patients with cardiac disease, creating an increased risk for severe COVID-19 complications, including heart failure. After SARS-CoV-2 binds with ACE2, the virus degrades it, and thus the free angiotensin II induces acute lung injury [58] . Thus, targeting the binding site of the ACE2 receptor and SARS-CoV-2 with antibodies or therapeutic drugs might provide a successful treatment strategy. Moreover, this also increases the level of soluble ACE2 that competitively binds with SARS-CoV-2, causing delayed entry of the virus into cells and protecting against lung injury. The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2	./cache/cord-314171-431buxxr.txt	./txt/cord-314171-431buxxr.txt