id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-314343-u8u7nq44	Sinclair, A.J.	Age, frailty and diabetes – triple jeopardy for vulnerability to COVID-19 infection	2020-04-23		.txt	text/plain	1132	57	46	The epidemiology of COVID-19 incidence, severity of illness and mortality seem to be shifted towards older people particularly those with multiple comorbidities such as diabetes, hypertension, and cardiovascular disease [1] . Older age was also identified as a risk factor for mortality from COVID-19 pneumonia in a Chinese retrospective, multicentre cohort study {odds ratio (OR) 1.10, 95% confidence interval (CI) 1.03 to1.17, p = 0¢004) [3] . In a meta-analysis of 8 Chinese studies to assess the prevalence of comorbidities in 46,248 infected patients with COVID-19, median age 46.0 years (51.6%) men, diabetes mellitus was the second most prevalent comorbidity (8%) after hypertension (17%) and higher than cardiovascular (5%) and respiratory diseases (2%) [2] . Although frailty was not formally assessed in the COVID-19 infection trials, old age associated with comorbidities including diabetes were associated with an increased risk of infection and worse outcome. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China	./cache/cord-314343-u8u7nq44.txt	./txt/cord-314343-u8u7nq44.txt