id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-315849-e16lln3f	Takayama, Kazuo	In vitro and Animal Models for SARS-CoV-2 research	2020-05-30		.txt	text/plain	1167	94	54	An in vitro cell model for SARS-CoV-2 research is essential for understanding the viral life cycle, for amplifying and isolating the virus for further research and for preclinical evaluation of therapeutic molecules. This section lays out the cell lines used to replicate and isolate SARS-CoV-2, as well as organoids that can be used to examine the effects of SARS-CoV-2 infection on specific human tissues (Table 1A, Figure 1 ). They showed that their organoids were permissive to the SARS-CoV-2 infection and could evaluate anti-viral effects of COVID-19 candidate therapeutic compounds including camostat [17] . who conducted SARS-CoV-2 infection experiments using HeLa cells that expressed ACE2 proteins taken from multiple animal species from mice to humans [11] . The team found that such mice after SARS-CoV-2 infection, showed weight loss, virus replication in the lungs, and interstitial pneumonia [25] . Human ACE2 transgenic mice After SARS-CoV-2 infection, the mice show weight loss, virus replication in the lungs, and interstitial pneumonia.	./cache/cord-315849-e16lln3f.txt	./txt/cord-315849-e16lln3f.txt