id author title date pages extension mime words sentences flesch summary cache txt cord-316080-y6ypbdtu Fajnzylber, J. M. SARS-CoV-2 Viral Load is Associated with Increased Disease Severity and Mortality 2020-07-17 .txt text/plain 1701 124 53 We quantified SARS-CoV-2 viral load from participants with a diverse range of COVID-19 severity, including those requiring hospitalization, outpatients with mild disease, and individuals with resolved infection. Amongst the participants hospitalized with COVID-19, higher prevalence of detectable SARS-CoV-2 plasma viral load was associated with worse respiratory disease severity, lower absolute lymphocyte counts, and increased markers of inflammation, including C-reactive protein and IL-6. Amongst hospitalized individuals, the majority still 92 had detectable SARS-CoV-2 RNA at the time of initial sample collection, including 50% with variable, individuals with detectable plasma, nasopharyngeal or sputum viral loads had 124 significantly lower absolute lymphocyte counts, and higher CRP and IL-6 levels compared to 125 those without detectable plasma viremia (Fig 2b-d) . . https://doi.org/10.1101/2020.07.15.20131789 doi: medRxiv preprint DISCUSSION 151 We report a comprehensive analysis of SARS-CoV-2 respiratory tract, plasma, and urine viral 152 loads of 235 participants who were either hospitalized with COVID-19, evaluated as 153 symptomatic outpatients, or had recovered from COVID-19 disease. ./cache/cord-316080-y6ypbdtu.txt ./txt/cord-316080-y6ypbdtu.txt