id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316579-p6pz14eo	Seheult, Jansen N.	Fibrinolysis Shutdown and Thrombosis in Severe SARS-CoV-2 (COVID-19)	2020-06-12		.txt	text/plain	1127	59	35	Fibrinolysis Shutdown and Thrombosis in Severe SARS-CoV-2 (COVID-19) Q1 Q3 Jansen N Seheult, Anupamaa Seshadri, Matthew D Neal Pittsburgh, PA The coagulopathy associated with the novel coronavirus SARS-CoV-2 (COVID-19) has emerged as a key driver of morbidity and mortality, especially in patients with severe disease. The markedly elevated D-dimer concentrations described in cases of severe COVID-19 is strongly suggestive of plasmin-mediated hyperfibrinolysis, which appears to be inconsistent with the finding of fibrinolysis shutdown on TEG. 10 In the setting of fibrinolysis shutdown observed in viscoelastic tests in patients with severe COVID-19, the source of the (often markedly) elevated D-dimer levels remains unclear. 13 Future research should profile the changes in activators and inhibitors of fibrinolysis, including tPA, PAI-1, and plasmin-antiplasmin complex levels over time, to further characterize the dynamic process of fibrinolysis in COVID-19, and should also study the role of neutrophil and monocyte activation in promoting thrombosis and altering fibrinolysis in patients with severe COVID-19.	./cache/cord-316579-p6pz14eo.txt	./txt/cord-316579-p6pz14eo.txt