id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316631-um0olqet	Park, Kyung Chan	Single‐cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID‐19 patients	2020-08-01		.txt	text/plain	963	61	53	title: Single‐cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID‐19 patients Several hypotheses have been put forward to explain these findings, 1,2 including pulmonary microvascular thrombosis, dysregulated hypoxic pulmonary vasoconstriction and dysfunctional gas transport by red blood cells (RBCs). 10 In a recent letter to this Journal, Hb oxygen affinity was shown to be unaltered in a cohort of 14 patients infected with SARS-CoV-2. When expressed in terms of the fraction of cells that release >95% of stored oxygen in a given time (equivalent to capillary transit), there was no effect of SARS-CoV-2 infection on RBC O 2 handling (Fig 2) . The cause of hypoxaemia in COVID-19 patients is therefore unlikely to relate to impaired O 2 handling by RBCs, either as a result of direct coronavirus infection or a consequence of the inflammatory state. Haemoglobin oxygen affinity in patients with severe COVID-19 infection	./cache/cord-316631-um0olqet.txt	./txt/cord-316631-um0olqet.txt