id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316938-64jxtg9y	Blasi, Annabel	In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID‐19 patients on anticoagulation	2020-08-06		.txt	text/plain	3076	163	41	CONCLUSIONS: COVID‐19 patients are characterized by normal in vitro thrombin generation and enhanced clot formation and decreased fibrinolytic potential despite the presence of heparin in the sample. Markers of NETs were modestly elevated in patients compared to controls, and did not differ between patients that were or were not admitted to ICU, which may argue against a key role of NETs in the pathogenesis of COVID-19 associated sequelae as was suggested previously. Plasma CLT was higher in COVID-19 patients compared to healthy controls, but similar between patients on ICU and ward. TAT and PAP complex levels are strongly elevated in patients with COVID-19, indicating ongoing thrombin and plasmin generation in COVID-19 patients despite anticoagulation with LMWH. Taken together, our data confirm a hypercoagulable status of enhanced thrombin generating capacity, enhanced ex vivo clot formation likely related to hyperfibrinogenemia, and a decreased ex vivo fibrinolytic capacity in patients with COVID-19. Decreased plasma levels of activated factor VII in patients with deep vein thrombosis	./cache/cord-316938-64jxtg9y.txt	./txt/cord-316938-64jxtg9y.txt