id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317622-o10ntfi8	Evans, Ronald M.	Shining Light on the COVID-19 Pandemic: A Vitamin D Receptor Checkpoint in Defense of Unregulated Wound Healing	2020-09-11		.txt	text/plain	4646	230	39	In patients, severity of liver disease correlates inversely with VDR expression, levels of vitamin D, and metabolites (Oh et al., 2020) , and hepatocellular injury directly with progressive COVID-19 (Henry et al., 2020; Ji et al., 2020) . Similar effects were observed in non-lung models; e.g., vitamin D deficiency (or VDR knockout) was associated with increased renin and Ang II (and IL-6 and TGFb) levels in diabetic mice (Zhang et al., 2008) . Human intestinal organoids (ACE2 expressing), suggesting a gut enterocyte reservoir for SARS-CoV-2, fuel viral spread and cytokine response in COVID-19 pathogenesis, another potential enteric-phase inflammatory hurdle to oral vitamin D administration (Clevers, 2020) . Heightened basal RAS (e.g., reduced ACE2 expression, higher Ang II levels) activation and inflammatory states (Ajilore and Thames, 2020; Albert and Ridker, 2004; Suthanthiran et al., 2000; Vinciguerra and Greco, 2020) , reported in African Americans, are associated with severe COVID-19 outcomes and relevant risk co-morbidities (e.g., hypertension, diabetes), some linked to vitamin D deficiency (Rostand, 2010; Yancy, 2020) .	./cache/cord-317622-o10ntfi8.txt	./txt/cord-317622-o10ntfi8.txt