id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317729-ruvx9zwd	Wilson, Darius Cameron	Adrenomedullin in COVID-19 induced endotheliitis	2020-07-09		.txt	text/plain	631	36	37	Indeed, a recent study investigating gene upregulation in patients with systemic capillary leak syndrome (SCLS), characterised by plasma leakage into peripheral tissue and transient episodes of hypotensive shock and oedema, found that ADM was not only one of the most upregulated genes, but that subsequent application to endothelial cells resulted in a protective effect on vascular barrier function [3] . Furthermore, recent clinical studies on sepsis patients upon emergency department (ED) presentation and during intensive care (ICU) treatment using the stable protein surrogate, mid-regional proadrenomedullin (MR-proADM), found that its assessment could accurately identify disease progression in patients with nonsevere clinical signs and symptoms, safely increase outpatient treatment with decreased readmission rates and no subsequent mortalities [4] , and identify patients requiring a rapid administration of antibiotics or triage to the ICU [5] . Abbreviations ADM: Adrenomedullin; ED: Emergency department; ICU: Intensive care unit; MR-proADM: Mid-regional proadrenomedullin; SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2; SCLS: Systemic capillary leak syndrome	./cache/cord-317729-ruvx9zwd.txt	./txt/cord-317729-ruvx9zwd.txt