id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318364-5bmdzgla	Sun, Xinjuan	Cytokine storm intervention in the early stages of COVID-19 pneumonia	2020-04-25		.txt	text/plain	3102	158	40	In a retrospective study of 41 patients with COVID-19, most patients with SARS-CoV-2 infection developed mild symptoms, whereas some patients later developed aggravated disease symptoms, and eventually passed away because of multiple organ dysfunction syndrome (MODS), as a consequence of a severe cytokine storm. In view of the severe morbidity and mortality of COVID-19 pneumonia, we review the current understanding of treatment of human coronavirus infections from the perspective of a dysregulated cytokine and immune response. In support of the above observations, a retrospective study of 41 patients with COVID-19 2 showed that most SARS-CoV-2 infected patients present clinically with mild symptoms, while a minority of patients progressively declined from the infection and eventually died of acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MOD). Severe pneumonia caused by pathogenic human coronaviruses (HCoV) are often associated with induced hypercytokinemia, also termed cytokine storm, in immunocompetent individuals; uncontrolled overproduction of inflammatory cytokines contributes to acute lung injury and acute respiratory distress syndrome (ARDS).	./cache/cord-318364-5bmdzgla.txt	./txt/cord-318364-5bmdzgla.txt