id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318938-7d731q65	Wallentin, Lars	Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation	2020-09-27		.txt	text/plain	4630	229	43	In unadjusted analyses and after adjustment for clinical variables and medical treatment, male sex, diabetes, congestive heart failure, prior myocardial infarction, and age were consistently associated with higher sACE2 levels in both cohorts ( Figure 3A ; Supplementary material online, Table S2 ). The results showed that higher levels of sACE2 were associated with male sex, cardiovascular disease, diabetes, and older age, which are also the main risk factors for complications and mortality of COVID-19 infections. The indication that male sex and clinical or biomarker indicators of biological ageing, cardiovascular disease, and diabetes might be associated with a specific mechanism leading to higher risk of more severe SARS-CoV-2 infection might be useful for risk stratification concerning COVID-19. The close association between biomarkers and the sACE2 level suggests that biological ageing and cardiovascular disease and dysfunction might lead to increased ACE2 expression and a potentially higher risk for SARS-CoV-2 binding and more severe COVID-19 infection.	./cache/cord-318938-7d731q65.txt	./txt/cord-318938-7d731q65.txt